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Acknowledgements This work was supported by the National Nature Science Foundation of China (82170830), grants from the 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (No

10.1136/jech-2021-218074 62 CanetG.HernandezC.ZussyC.ChevallierN.DesrumauxC.GivaloisL

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