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The liver makes most glutathione and other tissues and organs hold it too
In organotypic hippocampal slice cultures, Dihexa and Nle-AngIV similarly augmented spinogenesis, with control slices showing 7 spines per 50-m dendrite length, compared to 11 for both Dihexa and Nle-AngIV treated slices [1]
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Dosing is generally the same, though women may need to monitor side effects like water retention or glucose sensitivity closely
The use of antioxidants such as glutathione, NAC, and lipoic acid (LA) has been shown to inhibit starvation-induced osteocyte apoptosis, downregulate RANKL expression and the RANKL/OPG ratio, and partially restore OPG expression (50)
Nature 599 , 650656 (2021)
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