Combined GLP-1 and GIP receptor agonism at appropriate doses shows a safety profile similar to high-dose single-agent therapy, with nausea and gastrointestinal adjustment as the primary tolerability issuestypically resolving within 48 weeks
When patients lose weight too quickly, the body depletes fat stores rapidly, including the structural fat in the face and glutes
Most of the time, this is a salty or metallic taste
Importantly, always consult your practitioner before taking any drugs and adhere to all their guidelines
First, the sample size was relatively small, which limits the generalizability of the findings
STEP-1 extension showed semaglutide patients regained two-thirds of their lost weight within a year of stopping, and cardiometabolic improvements largely reversed