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IV delivery achieves 100% bioavailability making it the only route of administration that produces reliable, measurable aesthetic outcomes

Recent preclinical studies have demonstrated the potential of CRISPR-Cas9 genome editing to address key mutations underlying HCM, such as missense mutations in the MYH7 gene 318,319 and premature stop codon mutations in the MYBPC3 gene

However, these therapies are commonly accompanied by adverse gastrointestinal and cardiovascular effects that limit their use [12]

Confounding by severity and regression to the mean may be at play in the results from this study and further randomized prospective designs are needed to formally test the efficacy of these novel applications of these medications

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