Interestingly, in the frontal cortex, LipRSV treatment in CT animals was associated with reduced antioxidant enzyme activity together with increased ROS formation, suggesting a potential pro-oxidant or redox-disruptive effect in this brain region

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It means that anyone using it should understand they are in largely uncharted territory and proceed with appropriate caution and monitoring
If your product shows these signs, its effective concentration has likely decreased regardless of what the label states
Thus, the lack of in vivo experiments significantly impedes progress