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These include mitochondrial complex I dysfunction, impairment of ATP production, oxidative stress, neuroinflammation, endoplasmic reticulum (ER) stress and aberrant proteolytic degradation

doi: 10.1158/0008-5472.CAN-05-0626 127 Aguirre-GhisoJA

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In a recent randomized, double-blind, placebo-controlled clinical trial, Quer supplementation (500 mg/day, P.O for 8 weeks) evidently improved serum total antioxidant capacity (TAC) in postmyocardial infarction patients compared to the placebo group [126]

They are mild by design, but like any injection, they can cause reactions

Endocrinology 159 , 34463457 (2018)