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Adding neurons to the culture makes the model more representative of the interaction in the NVU and increases the sensitivity of the BBB integrity to oxygen-glucose deprivation [115]
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Some people may need a dosage of a medication that is lower than what is commercially available, or they may not be able to swallow a pill and thus need a medication compounded into liquid form
The STEP-1 trial (N=1,961) showed semaglutide 2.4 mg produced 14.9% mean body weight loss at 68 weeks versus 2.4% with placebo [1]
Supporting evidence ranges from modest to impressive, although larger randomized studies are still needed
