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Brenner sees his T-cell experiments as a prelude to more in-depth investigation of the energy balance of immune cells in general

Conclusion As the multi-hit hypothesis holds, combining the therapeutic approaches of GLP-1 agonists with resmetirom seems like a promising strategy by targeting the multifaceted pathophysiology of MASH, which may lead to improved patient outcomes

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M1 microglia are cytotoxic due to their release of proinflammatory cytokines, including IL-1 and TNF, and reactive oxygen species (ROS)