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Alteration of gut microbiota induced by DPP-4I treatment improves glucose homeostasis
Glucagon-like peptide-1 (GLP-1) receptor agonists, such as semaglutide and liraglutide, have gained attention for their ability to help with blood sugar management and weight loss
Lab Chip 17 , 653662 (2017) NIZO: Gutbrain axis on-chip
Experimental receptor assays demonstrate that GLP-RT functions as an agonist at all three receptors, although the peptide exhibits differing potency levels across the receptor set
Platforms that combine convenience with documented follow-up and local escalation routes are better positioned for sustained adoption
Additionally, thermosensitive nanogels and stimuli-responsive nanocarriers that respond to pH or glucose levels have been proposed for precision-controlled GLP-1 delivery, enabling intelligent drug release based on glycemic fluctuations
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