Technology Appraisal Guidance TA924
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Fundamentally, GLP-1RAs work by stimulating insulin secretion and inhibiting glucagon secretion in a glucose-dependent manner [9], which explains their associated low risk of hypoglycaemia
Diabetes care 27 (8), 18791884
Once mixed, the solution is stable at 28C for 28 days, but every needle puncture introduces contamination risk, so using a vial within 21 days and minimizing punctures (one draw per dose, never re-injecting air) extends usable life