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Tesofensine remains one of the most potent research tools for appetite suppression and thermogenesis

doi:10.1371/journal.pone.0150600

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The mechanistic logic NNMT inhibition preserving NAD+ salvage, increasing adipocyte energy expenditure, and protecting against diet-induced adipose accumulation in animal models places 5-Amino-1MQ in a distinct niche compared to the metabolic peptides that dominate the rest of the obesity-research landscape

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