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Certain conditions may blunt or impede therapeutic response to methylcobalamin therapy
Over-interpretation of secondary outcomes may lead to spurious inferences, underscoring the need for caution when translating these findings into clinical reassurance.This aligns with emerging data linking metabolic improvements such as weight loss, insulin sensitivity, and reduced inflammation to decreased malignancy risk in high-risk populations with type 2 diabetes or obesity (Marso et al., 2016a
According to NICE guidance (NG28) , GLP-1 agonists are recommended for type 2 diabetes when metformin and other treatments have not achieved adequate control