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In the CNS, GLP-1Rs are expressed by neurons in the hippocampus, which is known to be a cognition-related brain region, and have been observed in neocortical pyramidal neurons (Hamilton and Holscher, 2009)
10.1038/s41573-019-0053-0 19 El-LebedyD
To further ensure the robustness and directionality of these associations, we performed MR analysis on the positive loci, as well as reverse MR analysis on the proteome
Riccardi G, Rivellese AA
Diabetes 56:17611772
Pharmaceutical versions of GLP-1 are designed to mimic this natural hormone but last longer in the body, giving patients the metabolic benefits without the need for constant production
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