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Aim for at least 23 litres of water daily, more if youre active or in a hot climate

59 However, the mechanisms underlying heterogeneous treatment responses, independent of molecular subtype, remain poorly understood, and reliable predictive markers or biomarkers are still lacking

11 The degree of weight loss with metformin has varied in the literature (0.6%-13%) given the frequent use of diabetic medications known to influence body weight (e.g., insulin, sulfonylureas) and varied adherence to lifestyle modifications

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For instance, according to the International Diabetes Federation,537 million individuals were affected by diabetes worldwide in 2021, with more than 75% of adult diabetes cases occurring in low and middle-income countries