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Key safety concerns associated with unregulated peptide use include: Hypoglycaemia GLP-1 and GIP receptor agonists have a low intrinsic risk of hypoglycaemia when used alone, but this risk increases significantly if combined with insulin or sulfonylureas

If a patient with only a mildly elevated serum prolactin level has a pituitary macroadenoma, the diagnosis is more likely to be a non-prolactin-producing pituitary adenoma or other sellar mass causing the stalk effect

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