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Increased serum uric acid levels (hyperuricaemia) can arise from increased purine metabolism, increasing age and decreased renal excretion, and have harmful systemic effects
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2), adenosine triphosphate (ATP) grasp enzymes and amide bond synthetases (ABSs), have attracted attention because of their direct activation and amidation of carboxylic acids without the need for partnering enzymes 30,31,32,33,34,35