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The correct classification: Pure GLP-1 agonists: exenatide, liraglutide, lixisenatide, dulaglutide, semaglutide, efpeglenatide, orforglipron Dual GIP/GLP-1 agonists: tirzepatide Triple agonists (GIP/GLP-1/glucagon): retatrutide Retatrutide, approved in early 2026, adds glucagon receptor agonism to the dual GIP/GLP-1 mechanism

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Rosebush MS, Briody AN, Cordell KG

This article outlines the place of GLP-1 and GIP analogues in wider therapy, while also highlighting relevant cautions, contraindications and side effects, with the aim of supporting safe prescribing and use of GLP-1 and GIP analogues for glycaemic control in adults with T2DM

According to USDA Agricultural Research Service data based on NHANES, approximately 6% of adults aged 60 and older in the United States are vitamin B12 deficient, defined as plasma B12 below 148 pmol/L (2009)

Understanding the pharmacology of Wegovy helps explain why some individuals feel generally unwell