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Pharmacological inhibition of system xc - by compounds like Erastin and sulfasalazine (SSZ) blocks cellular cystine import, initiating a cascade of intracellular cysteine depletion, glutathione (GSH) exhaustion, GPX4 dysfunction, and consequent ferroptotic cell death (28)
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Short-term predictive indicators that are strongly correlated with clinical outcomes in MASLD are highly anticipated, but reliable surrogate endpoints are currently lacking
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IGF-1 elevations followed, increasing 1.5 to 3-fold for 9 to 11 days after a single dose
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