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Oral or Nasal Forms Less effective due to poor bioavailability

NatMed 2025), headache (NatMed 2025

Both disproportionality analyses confirmed this heightened risk: ROR analysis showed a statistically significant association (ROR = 1.81, 95% CI 1.622.03), while BCPNN yielded an information component of IC = 0.85 (IC025 = 0.69), both indicating substantially greater renal impairment risks in this older population treated with the combination therapy

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Ishii, K., Komaki, H., Ohkuma, A., Nishino, I., Nonaka, I., and Sasaki, M

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