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GLP-1R signaling in the brain exerts antidepressive effects by improving cognitive processes, promoting neuroprotection and neurotransmitter release Patients suffering from depression are characterized by impaired neuronal activity and synaptic plasticity dysfunction, resulting in volumetric changes in brain regions which regulate emotions or the stress response such as the hippocampus and the prefrontal cortex

I look at sourcing, consistency between batches, and whether the product has been properly handled from start to finish

The scale may move, but the dietary patterns driving heart disease, diabetes, and inflammation are still very much in place

PMID 15504997

However, the compound became widely available for routine use in the treatment of B12 deficiency in the early 1950s (8)

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