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People and mice differ in metabolism, body size, route exposure, and disease biology, so animal results cannot predict a person's outcome

its rationale comes from how the four component mechanisms fit together

total protein, crude fat, total dietary fiber and ash

Through the analysis of numerous in vivo and in vitro studies aimed at determining the mechanisms by which GLP-1 enhances insulin secretion in individuals with normal glucose tolerance or T2DM, two main intracellular mechanisms underlying the incretin effect have emerged

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These trials form the evidence base for FDA approval of Egrifta in 2010