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However, in resistant patients, oxidative stress causes a conformational change in Keap1, leading to the release of NRF2, which translocates to the nucleus and binds to antioxidant response element (ARE), activating the expression of downstream antioxidant genes, including GPX4, NQO1, HO-1 and SOD1 [33], and promoting the synthesis of GSH, as illustrated in Fig

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Other growth factors such as bone morphogenetic proteins (BMPs) have received FDA approval for specific indications and may represent more appropriate therapeutic choices for conditions where approved therapies are available and indicated

vant Hoff WG, Gretz N (1995) The treatment of cystinosis with cysteamine and phosphocysteamine in the United Kingdom and Eire

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