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The -propeller domain packs against the / hydrolase domain, and the catalytic triad (residues Ser630, His740 and Asp708) is located at the interface between the two domains (Aertgeerts et al., 2004)

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Chen et al., 2013)

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doi: 10.1111/dom.14286 23 CarusoICignarelliAGiorginoF

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Semaglutide carries an alpha-aminoisobutyric acid substitution at position 8 that blocks that cleavage, plus a C18 fatty-diacid side chain that binds reversibly to circulating albumin

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