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In future, to better understand the possible role of altered cognition and acceptance bias in this bi-directional relationship, longitudinal studies should measure changes in effort-based decision-making over time and assess how this relates to metabolic health changes

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We measured weight and BP from screening, so effects on total weight-loss maintenance could be determined post hoc

This slow titration allows brainstem GLP-1 receptors in the area postrema and nucleus tractus solitarius to accommodate to the agonist, reducing the nausea and vomiting that otherwise occur with initial exposure to potent GLP-1 receptor activation

They subsequently provided informed consent to the healthcare facility

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