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Shared decision-making : If considering offlabel or prevention use, open discussion of uncertain benefit, possible side effects, cost, monitoring is essential

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This process ultimately suppresses HSC activation (reducing -SMA expression), inhibits the mRNA expression of type I and III collagen, reduces the production and deposition of ECM, mitigates fibrotic tissue hyperplasia and pseudolobule formation, and thereby reverses liver fibrosis (Zhang et al., 2022)