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4.4 MTH1 is associated with tumor drug resistance In human breast cancer cells, particularly MCF7-R, the knockdown of MTH1 activated the expression of the cell cycle protein-dependent kinase inhibitory protein p21
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The drug increased the likelihood of achieving at least 5% body weight loss but was associated with higher rates of mild-to-moderate gastrointestinal side effects
Vermutlich hat die PKA inhibierende Einflsse auf ATP-abhngige Kaliumkanle (Target der Sulfonylharnstoffe/Glinide) in den -Zellen des Pankreas
Translational percentages (concordance rates) of results exhibit a wide range from 0100% with no predictable factors for translational success or failure in humans (309), and even multiple experiments fail to significantly contribute to improving the reproducibility of animal testing, accounting for 41%72% of the observed total variance (310, 311)
PMID 11511307
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