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In the STEP 1 trial, about 74% of participants on semaglutide experienced GI side effects (nausea, vomiting, diarrhea, or constipation) (source)
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By enhancing insulin secretion only when blood sugar is high, GIP provides a safety net that reduces the risk of hypoglycaemia
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Treatment with LY2409021, a glucagon receptor antagonist, increases liver fat in patients with type 2 diabetes
As such, it has been used for the management of diabetes for the last few years under the trade name Victoza
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