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Noteworthy, pharmacological induction of HO-1 has been reported to elicit neuroprotective effects against the neurotoxic A-protein aggregates (Wang et al., 2016) and hamper the replication of HSV in a human neuronal cell line, although this was determined using HSV-2 (Ibez et al., 2017)
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Real-world data shows that roughly 40-50% of requests for branded GLP-1 coverage face initial denial or require step therapy, meaning patients often wait weeks before approval or must absorb out-of-pocket costs upfront
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After release from serotonergic neurons, most of the released serotonin is recaptured by an active reuptake mechanism
