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liraglutide is injected daily The longer duration of action is the main reason Wegovy produces greater weight loss Weight loss: what the evidence shows Head-to-head trial: STEP 8 Unlike many medication comparisons, we have a direct head-to-head randomised controlled trial comparing semaglutide and liraglutide for weight loss

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Additionally, variations in dosing equivalence, species-specific GLP-1 receptor expression, and metabolic responsiveness further complicate the direct translation of these findings to human diseases (De Giorgi et al., 2025)

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