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264,265,266 Keap1 is an adaptor of cullin-based E3 ubiquitin ligase that suppresses the transcriptional activity of Nrf2 via inducing its ubiquitination and proteasomal degradation

[3] At the 12 mg dose, the mean weight reduction was about 17.5% at 24 weeks (the primary endpoint) rising to roughly 24.2% at 48 weeks , compared with about 2.1% for placebo

Vitamin C is a water-soluble vitamin that plays a crucial role in immune function, collagen synthesis, and antioxidant defense, and may also support cardiovascular health and cognitive function

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