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In summary, incretin receptor agonists demonstrate consistent anti-fibrotic effects in vivo , reducing hepatic stellate cell activation, oxidative stress, and collagen deposition in animal models, and improving fibrosis outcomes in clinical MASLD and MASH studies

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A 2024 pharmacokinetic modeling study (Urva et al., Clinical Pharmacokinetics ) simulated early dosing scenarios and found that dosing 48 hours early increased the risk of nausea by 42% and vomiting by 38% compared to on-schedule dosing during the overlap window

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