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GLP-1 compounds are processed primarily through the kidneys and liver, so patients with moderate to severe kidney or liver disease should discuss GLP-1 therapy with their physician before starting

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Whilst no official contraindication exists, the combination presents both potential benefits and significant considerations

Other Emerging Mechanisms Beyond multi-agonist drugs, researchers are exploring other novel pathways for treating obesity

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For tirzepatide, some animal data may be available, but it does not always predict what happens in human breastfeeding