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This aligns with the mechanistic literature

Under hypoxia, the activity of the prolyl hydroxylases is inhibited, due to both lower oxygen availability and ROS generation by the mitochondria

2014;5:181 Gunnarsdottir S, Rucki M, Elfarra AA

May 2020;50:102393

The MTHFD1 encoded enzyme possesses three activities that include, N 5 , N 10 -methenyl-THF (5,10-methenyl-THF) cyclohydrolase, 5,10-methylene-THF dehydrogenase, and 10-formyl-THF synthetase