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Molecular aspects of medicine 29 , 916, doi: 10.1016/j.mam.2007.09.004 (2008)

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However, these results have not been confirmed yet in larger, randomized, well-controlled trials and the drug is not approved for use in the United States

Fact 07 Argireline shows 48.9 percent subjective wrinkle improvement versus 0 percent placebo in clinical trial when delivered effectively, with topical penetration as the main efficacy ceiling

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In a 9-month monkey oral toxicity study, all female monkeys in the high-dose group showed minimal-to-slight periportal hepatocyte vacuolation