Having an adequate blood level of vitamin D when starting a GLP-1 medication may slightly improve outcomes, according to a recent study
A pilot study showing acute inhibitory effect of GLP1 on the bone resorption marker CTX in humans
General Safety Profile Based on the preclinical dataset and the limited human exposure data: No prominent signal of hepatic, renal, or hematological toxicity at tested doses No prominent cardiovascular safety flag Pregnancy and lactation as with most research compounds, safety not established Long-term effects not characterized What Clinicians Should Actually Tell Patients For patients asking about 5-amino-1MQ, a reasonable response framework: What the compound is: A research-stage small molecule inhibiting NNMT with promising preclinical fat loss data
References Sies H
Dehydration during weight loss increases fatigue, reduces metabolic rate, and slows fat breakdown
Thats the reasoning behind recommendations that people take a 50-food challenge, eating at least fifty different plant foods a week to achieve a diet diverse enough to feed a vast spectrum of bacteria