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Clinical manifestations of the patients were diverse, including aggravated edema, decreased appetite, fatigue, altered mental state, oliguria, shortness of breath, reduced urine output, nausea, vomiting, diarrhea, jaundice, abdominal pain, progressive edema, fever, chills, and constipation

Patients who require slower titration due to gastrointestinal side effects may experience a delayed onset of maximal appetite control

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J Lipid Res