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Hypertension 2010;55(2):e13

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Specifically, this sequence sequesters G-actin monomers, reducing filamentous actin polymerization and promoting the cellular migration required for wound closure and tissue repair

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The cleaved N-terminal fragment of GSDME forms pores in the cell membrane, triggering pyroptosis, which is characterized by cell swelling, rupture, and the release of pro-inflammatory signals

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