Elevated leptin in obesity often reflects leptin resistance, where impaired hypothalamic signaling and reduced leptin transport across the bloodbrain barrier limit its appetite-suppressing effects [68, 69]
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While some patients adapt, others face significant quality-of-life impacts, including reduced food intake, dehydration risk, and compromised nutritional status if not monitored by a healthcare provider
The study found no increase in pancreatic cancer risk with GLP-1RA use, and several sensitivity analyses suggested a modest, non-significant reduction in incidence (Wang et al., 2025)
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