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This adaptation presents a targetable vulnerability whereby the functional inhibition of this adaptive response greatly increased the effectiveness of 5FU across CRC models in vitro and in vivo

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Astrocytic atrophy following status epilepticus parallels reduced Ca 2+ activity and impaired synaptic plasticity in the rat hippocampus

This neutralizing effect is mediated by a family of glutathione peroxidase enzymes (GPx)

Other documented findings include a tendency toward IGF-1 receptor desensitization with prolonged, continuous exposure, transient fluid retention in early study phases, and at supraphysiological exposure levels examined in some research acromegaly-like tissue changes

"A performance evaluation of three drug-induced liver injury biomarkers in the rat: alpha-glutathione S -transferase, arginase 1, and 4-hydroxyphenyl-pyruvate dioxygenase" (PDF)