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The combined effect produces weight loss results that exceed what either approach achieves alone

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GLP-1 therapies act comprehensively on this metabolic substrate, simultaneously addressing insulin resistance, hepatic inflammation, adipokine dysregulation, and systemic oxidative stress

In particular, ECL1 and ECL3, which were disordered in the previous TMD structure, are now ordered and form a -helical conformation reminiscent of the peptide-bound GLP-1R structures