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Nrf2MafG heterodimers contribute globally to antioxidant and metabolic networks

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The result is oxidative stress (OS) which is linked to numerous disease processes including cognitive decline (Alzheimers disease) and other age-related conditions like cancer, cardiovascular disease, and diabetes

This means that oral GLP-1s require much higher doses just to achieve similar effects, and even then, absorption can vary based on factors like water intake, stomach pH, and timing of meals

However, because GLP-1 medications slow the stomachs emptying process, food may remain in the stomach longer than expected, even after fasting