From a methodological standpoint, most analyses demonstrated moderate risk of bias with sound statistical adjustment (IPW, matching, multiple imputation) but limited causal inference due to observational design
This natural reduction in collagen affects not only our physical appearance, such as decreased skin elasticity, but also the functional integrity of our joints and muscles
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The international journal of biochemistry & cell biology , 37 (8), 1727-1737
The innovations in drug design and formulation that we just covered, including dual and triple agonists or conjugates with other hormonal pathways, are helping driving this expansion by delivering greater weight loss and metabolic benefits while reducing side effects through synergistic mechanisms