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While natural presence in the body is reassuring, supplementation introduces higher concentrations than the body typically manages, which can occasionally lead to side effects, particularly in vulnerable populations or when combined with certain medications
A direct thiol donor given IV when supplementation urgent (e.g., oxidant challenge / fulminant hepatic failure)
There are no other officially reported contraindications specific to NAD+ as of now, but the absence of documented contraindications largely reflects limited clinical study
Extend the injection window earlier and accept a slightly smaller response, or reduce evening meal size
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