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By bridging these gaps, GLP-1RAs could herald a new era in pain management, offering hope for patients with refractory or complex pain conditions

However, it was observed that despite the improvement in blood glucose levels in insulin-resistant pregnant rats, metformin also aberrantly activated AMPK and stimulated glycogenolysis in the endometrium ( 2.2.2 Modulation of the expression of relevant hormone receptors affects endometrial metamorphosis The collaborative function of progesterone (P4) and estradiol (E2) is essential for establishing endometrial tolerance during the implantation window period in the natural reproductive cycle of mice ( 2.2.3 Others Metformin influences the production of advanced glycation end products (AGEs) and the generation of ROS through the activation of AMPK, inhibition of the receptor for advanced glycation end products/nuclear factor kappa B (RAGE/NF-B) signaling pathway, and modulation of gene expression

Type 2 diabetes mellitus (T2DM) is one of the major subtypes of DM, and its pathogenesis is more complex, involving insulin resistance and insulin secretion dysfunction (Xourafa et al., 2024)