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doi:10.1007/978-3-319-22539-5_14

Motor neurons overexpressing mSOD1 secreted a proportion of the mSOD1 protein [134], which might be recognized by the C1q-induced complement system and mark the motor neurons for attack by immune cells

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Pharmacokinetic (PK) objectives vary: some protocols test short-acting pulses that mirror meal-time signaling, while others emphasize sustained exposure to probe AUC-dependent effects

In clinical trial data, nausea, diarrhoea, constipation and vomiting are consistently among the most common side effects

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