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The dose-response relationship is entirely different from semaglutide, where dosing follows a fixed titration schedule

Several technical reasons may explain our distinctive findings, including differences in the microbiome sampling site, the limited n per group, singly housing mice, or the use of highly similar lean, Western, and high-fat diets which systematically exchanged fat content with carbohydrate content

doi: 10.1016/0196-9781(86)90167-1 60 TsengCCKiefferTJJarboeLAUsdinTBWolfeMM

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The long-term health benefits and reduced healthcare costs make these therapies a prudent investment for health systems globally

For additional information on obesity rates and racial disparities, see KFFs policy watch: What are the Implications of New Anti-Obesity Drugs for Racial Disparities