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3.5 Meta-analysis The included studies showed substantial heterogeneity (I 2 = 99.6%, p 0.05), supporting the conclusion of comparable efficacy and the lack of a clear doseresponse relationship

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High oral bioavailability Caco-2 cell assays showed excellent passive and active membrane transport with no detectable efflux (Neelakantan et al., 2018)

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Different investigations may utilize different formulations, dosing approaches, or treatment durations, making it challenging to compare results across studies and establish optimal therapeutic protocols