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Tirzepatide is a medication that improves insulin sensitivity, which can be evaluated indirectly through fasting biomarkers such as glucose and insulin and the homeostasis model assessment of insulin resistance (HOMA2-IR)

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(See Section 9: Pharmacologic Therapy, recommending GLP-1 RA for T2D with ASCVD) Wilding JPH, et al

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The measure follows WHO (World Health Organization) guidelines on the use of GLP-1 drugs as allies in tackling obesity.