Symptoms like nausea, fatigue, reflux and other gastrointestinal symptoms are common during the early weeks of treatment and after dose increases
Nonetheless, state rules can impose some extra limitations depending on the purpose of use
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This is associated with increased food intake in the FAS knock-out mice demonstrating that malonyl-CoA levels are indeed responsible for the hypophagic effects observed in the FAS knock-out mice
Dose-dependent nausea is dramatically worse at higher starting doses