Mitsumoto H, Santella RM, Liu X, Bogdanov M, Zipprich J, Wu HC et al
During a hemolytic crisis in someone with G6PD, bilirubin levels build up above expected levels
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doi: 10.1016/S0261-5614(17)30566-6 41
274,275 This, in turn, diminishes additional downstream effects, including oxidative stress, the secretion of pro-degradative substances, modifications to cell phenotype (hypertrophy, M1/M2 macrophage phenotype, fibrosis), and damage or deterioration of joint cells (apoptosis, senescence)